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MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:
1. A 50-year-old woman noticed some swelling of her right great toe and a painful right foot. She had type 1 diabetes mellitus of 21 years' duration and recent screening had revealed some mild diabetic retinal changes and peripheral neuropathy.
On examination, she had a hot, red right forefoot with swelling of the great toe. There was callus on the first metatarsal head with a blister beneath it. After de-roofing, the podiatrist probed to a depth of 1 cm. The left foot demonstrated reduced sensation to a 10-g monofilament. Her right foot was 0.6C hotter than the left.
What is the most likely diagnosis?
A) necrotising fasciitis
B) osteoarthritis
C) Charcot's foot
D) osteomyelitis
E) gout
2. A 26-year-old woman with type 1 diabetes mellitus was seen in the antenatal diabetes clinic and was 8 weeks pregnant. The father of her child also had type 1 diabetes mellitus. They were concerned that their child might develop type 1 diabetes mellitus.
What is the likelihood of the child developing type 1 diabetes mellitus?
A) 0.1-1%
B) 5-10%
C) 55-75%
D) 25-40%
E) 85-100%
3. A 27-year-old woman presented with a 6-month history of amenorrhoea and low mood. She complained of headaches but no visual disturbance. Her past medical history included anorexia nervosa but her current weight was stable.
On examination, her body mass index was 20.2 kg/m2 (18-25). Routine physical examination was normal and there was no galactorrhoea. Visual fields were full to confrontation.
Investigations:
serum cortisol (09.00 h)320 nmol/L (200-700)
short tetracosactide (Synacthen@) test (250 micrograms): serum cortisol (30 min after tetracosactide)630 nmol/L (>550) serum oestradiol200 pmol/L (200-400) plasma follicle-stimulating hormone2 U/L (2.5-10.0) plasma luteinising hormone4 U/L (2.5-10.0)
serum prolactin1001 mU/L (<360) serum free T418.0 pmol/L (10.0-22.0)
serum ?-human chorionic gonadotropin<5 U/L (<5)
What is the most appropriate next step in management?
A) ultrasound scan of ovaries
B) MR scan of pituitary
C) start cabergoline 0.5 mg/week
D) encourage weight gain and reassess after 2 months
E) pregnancy test
4. A 59-year-old man with an 8-year history of type 2 diabetes mellitus was seen in the outpatient clinic. He had worsening renal function in the absence of microalbuminuria.
On examination, his blood pressure was 175/90 mmHg. He had a femoral bruit, and absent dorsalis pedis pulses bilaterally.
Investigations:
serum creatinine150 umol/L (60-110)
estimated glomerular filtration rate (MDRD)39 mL/min/1.73m2 (>60)
In addition to addressing his blood pressure, what is the most appropriate next investigation?
A) captopril diethylene triamine pentacaetic acid (DTPA) scan
B) mercaptoacetyltriglycine (MAG3) renography
C) lower limb angiography
D) renal ultrasound scan with Doppler studies
E) MR angiography of renal arteries
5. A 64-year-old man, who was undergoing investigation for altered bowel habit, was referred to the endocrine clinic after a CT scan of abdomen had shown a 4-cm mass in his left adrenal gland. He had a history of hypertension and type 2 diabetes mellitus.
Investigations:
low-dose dexamethasone suppression test (2 mg/day for 48 h):
serum cortisol350 nmol/L (<50)
24-h urinary free cortisol400 nmol (55-250)
plasma adrenocorticotropic hormone (09.00 h)2.0 pmol/L (3.3-15.4)
He underwent laparoscopic removal of his left adrenal gland.
How should his endocrine condition be managed following surgery?
A) start hydrocortisone perioperatively and continue until tetracosactide (Synacthen@) test in 6 weeks
B) tetracosactide (Synacthen@) test 6 weeks postoperatively and start hydrocortisone if abnormal
C) 24-h urinary cortisol 6 weeks postoperatively and start hydrocortisone if abnormally low
D) immediate postoperative tetracosactide (Synacthen@) test and, if abnormal, start hydrocortisone
E) introduce hydrocortisone and fludrocortisone postoperatively according to blood pressure and electrolytes
Solutions:
Question # 1 Answer: D | Question # 2 Answer: D | Question # 3 Answer: B | Question # 4 Answer: E | Question # 5 Answer: A |

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